dynasore (Selleck Chemicals)
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Structured Review
Selleck Chemicals
dynasore
Dynasore, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 43 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/dynasore/Genistein/pmc13681822-43-0-14
Average 94 stars, based on 43 article reviews
Dynasore, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 43 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/dynasore/Genistein/pmc13681822-43-0-14
Average 94 stars, based on 43 article reviews
dynasore - by Bioz Stars,
2026-11
94/100 stars
Images
1) Product Images from "Trophoblast derived extracellular vesicles trigger secondary vesicle release from endometrial epithelial cells"
Article Title: Trophoblast derived extracellular vesicles trigger secondary vesicle release from endometrial epithelial cells
Journal: Cell Communication and Signaling : CCS
doi: 10.1186/s12964-026-03096-4
Figure Legend Snippet: Different chemical modulators related to EV uptake
Techniques Used: Binding Assay, Blocking Assay, Activity Assay
Figure Legend Snippet: Endocytosis inhibition attenuated the EV mediated embryo maternal cross-talk. a-b The in vitro embryo implantation model and the experimental design used to study EV mediated embryo maternal cross-talk. c Various EV uptake pathways and the mechanisms of action of the chemical inhibitors used to block each pathway. d-i Evaluation of cytotoxicity at the selected inhibitor concentrations. DMSO (chlorpromazine, dynasore, wortmannin, cytochalasin D and genistein) or sterile water (heparin) was used as the vehicle control. j-o RL95-2 cells were pre-treated with selected concentrations of chlorpromazine (10 µM), dynasore (20 µM), wortmannin (1 µM), heparin (20 µg/mL), cytochalasin D (10 µM), and genistein (50 µM) for 30 min and then the cells were treated with JAr EVs at 10 9 EVs/mL concentration along with fresh inhibitor for another 30 min. The MFGE8 concentration in cell culture supernatants were measured using MFGE8 ELISA. The results from three or more independent experiments were summarized as the mean ± SD ( n = 3). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001
Techniques Used: Inhibition, In Vitro, Blocking Assay, Sterility, Control, Concentration Assay, Cell Culture, Enzyme-linked Immunosorbent Assay
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For spatial proteomics experiments, per replicate, approximately 100×10 6 Casp1/11 -/- or Asc -/- SILAC-heavy or -light labelled iBMDMs were primed with 1 μg/ml LPS-EB or LPS-EB Ultrapure from E. coli 0111:B4 (InvivoGen, #tlrl-eblps or #tlrl-3pelps) in CM for 4 h at 37°C, 5% CO 2 , followed by stimulation in serum free conditions with either 10 μM Nigericin (NI; Thermo Fisher Scientific, #N1495), 60 μg/ml R837/Imiquimod (InvivoGen, #tlrl-imqs-1), 10 μM monensin (Merck, #M5273), Mdivi-1 (Selleckchem, #S7162), K + -free Hank’s balanced salt solution (HBSS), 160 μM Multiplex sample analysis:Article Title: NLRP3 activators disrupt the endocytic AP2 complex and plasma membrane signaling Article Snippet: .. For spatial proteomics experiments, per replicate, approximately 100×10 6 Casp1/11 -/- or Asc -/- SILAC-heavy or -light labelled iBMDMs were primed with 1 μg/ml LPS-EB or LPS-EB Ultrapure from E. coli 0111:B4 (InvivoGen, #tlrl-eblps or #tlrl-3pelps) in CM for 4 h at 37°C, 5% CO 2 , followed by stimulation in serum free conditions with either 10 μM Nigericin (NI; Thermo Fisher Scientific, #N1495), 60 μg/ml R837/Imiquimod (InvivoGen, #tlrl-imqs-1), 10 μM monensin (Merck, #M5273), Mdivi-1 (Selleckchem, #S7162), K + -free Hank’s balanced salt solution (HBSS), 160 μM Dominant Negative Mutation:Article Title: NLRP3 activators disrupt the endocytic AP2 complex and plasma membrane signaling Article Snippet: .. For spatial proteomics experiments, per replicate, approximately 100×10 6 Casp1/11 -/- or Asc -/- SILAC-heavy or -light labelled iBMDMs were primed with 1 μg/ml LPS-EB or LPS-EB Ultrapure from E. coli 0111:B4 (InvivoGen, #tlrl-eblps or #tlrl-3pelps) in CM for 4 h at 37°C, 5% CO 2 , followed by stimulation in serum free conditions with either 10 μM Nigericin (NI; Thermo Fisher Scientific, #N1495), 60 μg/ml R837/Imiquimod (InvivoGen, #tlrl-imqs-1), 10 μM monensin (Merck, #M5273), Mdivi-1 (Selleckchem, #S7162), K + -free Hank’s balanced salt solution (HBSS), 160 μM Control:Article Title: NLRP3 activators disrupt the endocytic AP2 complex and plasma membrane signaling Article Snippet: .. For spatial proteomics experiments, per replicate, approximately 100×10 6 Casp1/11 -/- or Asc -/- SILAC-heavy or -light labelled iBMDMs were primed with 1 μg/ml LPS-EB or LPS-EB Ultrapure from E. coli 0111:B4 (InvivoGen, #tlrl-eblps or #tlrl-3pelps) in CM for 4 h at 37°C, 5% CO 2 , followed by stimulation in serum free conditions with either 10 μM Nigericin (NI; Thermo Fisher Scientific, #N1495), 60 μg/ml R837/Imiquimod (InvivoGen, #tlrl-imqs-1), 10 μM monensin (Merck, #M5273), Mdivi-1 (Selleckchem, #S7162), K + -free Hank’s balanced salt solution (HBSS), 160 μM Inhibition:Article Title: Proinflammatory circulating extracellular vesicles from type 1 diabetes patients contribute to beta cell cytotoxicity and disease pathogenicity Article Snippet: For assessing the effect of serum, plasma and EVs on β- or α-cell cytotoxicity, mouse or human islet cells were cultured for 24h in media containing FCS (control), or in media where the FCS was substituted with either serum or plasma (10% v/v), or in media containing EV-free FCS and treated with mouse or human EVs (5-20 μl of EVs or 50-100 μg of EV protein/ml), or with EV-depleted fraction, or treated with a mix of human cytokines (IL1β 50U, 0.714 ng/ml; IFNγ 1000U, 50 ng/ml; and TNFα 1000U, 13.15 ng/ml) (R&D Systems, Minneapolis, MN) as positive control for cell death. .. For EV uptake inhibition human islet cell cultures were pre-treated with vehicle or Clinical Proteomics:Article Title: Proinflammatory circulating extracellular vesicles from type 1 diabetes patients contribute to beta cell cytotoxicity and disease pathogenicity Article Snippet: For assessing the effect of serum, plasma and EVs on β- or α-cell cytotoxicity, mouse or human islet cells were cultured for 24h in media containing FCS (control), or in media where the FCS was substituted with either serum or plasma (10% v/v), or in media containing EV-free FCS and treated with mouse or human EVs (5-20 μl of EVs or 50-100 μg of EV protein/ml), or with EV-depleted fraction, or treated with a mix of human cytokines (IL1β 50U, 0.714 ng/ml; IFNγ 1000U, 50 ng/ml; and TNFα 1000U, 13.15 ng/ml) (R&D Systems, Minneapolis, MN) as positive control for cell death. .. For EV uptake inhibition human islet cell cultures were pre-treated with vehicle or |